Egyptian Days: magical science

Anything handed down from the distant past had extra authority, and when it came from the East, even more so. Until well into the early modern period, one of the firmest universal beliefs was in the unlucky Egyptian Days.

The Lacnunga Manuscript carefully instructs doctors that there are three days in the year when they must not bleed either animals or men, no matter how sick they were. Blood-letting had not yet acquired the pseudo-scientific footing it had in the 17th and 18th centuries, but it was considered a good, responsible part of health care. Farmers bled their horses once a year (right after Christmas, on St. Stephen’s Day). Monks, the only class of people who received regular, institutionalized health care, had a right to be bled several times a year on a regular schedule, spending a night in the infirmary to recover.

But those scheduled days must never include the Egyptian Days! On those days, it was very unlucky to create a bleeding situation. Within a few days, the man or beast who had thinned his blood would die. He had at most a week, and if he took a strengthening drink to overcome his fate, he would still die within two weeks. Egyptian Days were also terrible luck for births. Such babies could live, but they would die “an evil death.” The last thing that must not be done on an Egyptian Day was to eat roast goose. Due penalty would be paid: death within 40 days.

The concept of Egyptian Days dates back to ancient times, to the Assyrians of Babylon.

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Magical obstetrics

There is something ultimately mysterious about the birth of a child, even now. We don’t know what governs sex selection in conception of a child, why some babies are stillborn, why some identical twins are conjoined, or how mutations happen. Even in our scientific times, we can only say that these things happen. Something like natural magic is behind it, even if we hope to chip away at the unknown.

How much more was it magical in the past, when natural magic was yet part of their science! Herbs or roots might help by some chemical process, or they might help by means of natural magic principles—who could tell? and all this was doubly true with women, pregnancy, and childbirth.

While Bald’s Leechbook majors in herbal and (for their time) scientific remedies, with only a few charms, the charms are present. The later Lacnunga manuscript mixes science and magic to a much greater degree. Its women’s health section is all magic. (Thank you Steve Pollington for the collection and translations.)

The Lacnunga book has a charm against stillbirth: Step over a dead man’s grave three times, reciting these words, “This as a relief to me for the hateful slow birth, this as a relief to me for the sad stillbirth, this as a relief to me for the hateful lame birth.” When she is pregnant and must lie down in bed at night, she should step across her husband, saying “I step over you with a living child, not a dead one, with a full-term baby, not a stillbirth.” And when the pregnant woman feels the baby kicking and knows it is alive, she should go to a church and say, “To Christ I said and declared this.”

The stillbirth charm probably predates Christian conversion; it must have been a charm to Nerthus or Freya. But in this late, Christian time, the woman is to make it piously clear that she is now saying these things to Christ.

Lacnunga’s further charm for inability to carry a child to term is darker: take a “piece” of her dead infant’s grave (handful of earth? piece of coffin? scrap of shroud?), and wrap it in black wool. Apparently this meant folding it up in several yards of cloth, so that it appeared to be a normal bolt of wool. The next step was to sell it to a trader and say, probably behind his back, “I sell it, you buy it, the black wool and seeds of my sorrow.”

We see here one of the principles of natural magic: to trap a source of trouble in some object and then remove it so that it can’t come back. The trader, unaware that he was buying a bolt with something tucked inside, would put it into his cart or ship and head to a large market town. There, it could be purchased by anyone. By the time they unfolded the black woolen bolt, and discovered the charm tucked inside, they would be so far away that bad luck could not find its way back.

This principle is also very alive in the last charm for stillbirth. This one is the most complicated, requiring a cow, a brook, two houses, and some food. The cow had to be all of one color, not brindled. Having milked this cow, and with some food in hand, the woman is ready.

She starts out, in one of the houses, sipping the milk from her hand without swallowing it. With her mouth full, she runs to the brook without looking behind, and spits the milk into the running water, where it is washed away. Then she scoops up some of the water and drinks it. She recites this charm: “Everywhere I have carried the splendid stomach-strong, with this splendid well-fed one, which I wish to have for myself and go home.” She then turns from the brook without looking back, leaving the source of trouble behind, washed downstream. She returns to a different house, “and takes food there.”

The charm has a clever touch that isn’t captured in modern English. In the phrases “splendid strong stomach” and “splendid well-fed,” the words are almost the same: “maeran magathihtan” and “maeran metethihtan.” The words seem to bind together, magically, the strength of one (the mother’s body) with the other (the infant who needs to be fed on “mete”). The word “food” that she must take into the house she enters is also “mete.”

Of course they didn’t work. But they must have felt as comforting and compelling as any placebo, and perhaps more so than many medical supports.

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Medieval gynecology

Early medieval traditional medicine gave due respect to the particular needs of women. Irregular periods and infertility, labor that’s timely and complete, and post-birth appearance of milk were the three basic problems for women. Some of the herbal remedies are still used, such as nettle tea, while others seem unlikely to be effective. But in women’s care, magic has an unshakable presence. Even apparently medical remedies may have been based in magical ideas.

Bald’s Leechbook, earliest of the Anglo-Saxon sources, does its best to steer clear of magic. (My source is Stephen Pollington’s Leechcraft.) For loss of menstrual periods, it recommends a complicated treatment plan. During the week when the bleeding should be expected, the woman will need a very warm bath every day. (This meant firewood, hauling extra water, and filling the largest wooden-stave tub.) While she sits in the bath, the woman is to drink ale, first boiled up with the herbs speedwell and centaury. After the bath, she is to be covered up very warm, and the doctor applies a poultice to her genital area: barley meal and the dregs of beer made with barley, wild celery, and mugwort. This process should be repeated as needed until the problem is corrected.

On the other side, the period may be dangerously heavy. For this problem, Bald’s treatment is a lot less pampering. The woman had to stand across a small fire with fresh horse droppings laid on its coals, so that this smoke fills her dress and makes her legs sweat. I don’t know what to make of this idea, but it seems to have been meant as a practical remedy, not as a charm. Dried (but fresh) horse droppings, crushed into a powder, are recommended for sores that won’t dry up. It seems possible that digestive enzymes (or something along that line) in the fresh droppings were medicinal.

Bald’s book also addresses problems with labor. When labor doesn’t start, boil a parsnip or carrot in milk and water (equal parts of both), then both eat the cooked root and sip the drink.  If this didn’t work, then a charm: have a child of either sex tie a henbane root or 12 coriander seeds (probably in a little linen bag) to the woman’s thigh. This charm had some risk, because if it remained in place after the baby’s birth, it might continue to draw out the insides of the baby itself. When the placenta did not emerge as expected, the midwife was to boil “old bacon” in water and use this as a douche.

Bald’s pregnancy care directions aren’t far off from some of our ideas. He seems aware of pregnancy food cravings, telling the doctor to “earnestly” refuse to let the woman eat anything very salty, sweet, fatty, or alcoholic. If she must be on a horse, the ride must be gentle, and she must not travel far, lest it induce premature labor. These directions must not have been easy, since avoiding alcohol meant boiling water frequently, and pork was a very common type of meat.

Next: Magical health care for women

 

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Mad dogs and Englishmen—and chickens

I’m passing over many remedies in Leechcraft that follow a sensible, generic pattern: “take these 3 herbs and boil them in wine, let the patient drink it.” “Boil this herb in butter, mix in another herb, apply to wound.” Many of them sound plausible. Another generic pattern is a long list of herbs to be ground together and mixed into butter as a heal-all salve. This, too, sounds at least plausible. There are simply so many of these remedies that unless readers wanted to know about a particular ailment, such as breaking up stones in the bladder, I don’t want to write about them. Of course, the risk of seeking out the interesting ones is that it may distort the overall picture of traditional medicine in the early Middle Ages.

Remedies for dangerous bites stand out from general wound care. There is more attention to snake bites in the Herbarium, which was compiled in Anglo-Saxon from Latin sources. Bald’s Leechbook is more interested in bites of spiders and dogs. However, the Herbarium addresses rabies in particular: the bite of a mad dog. It probably didn’t work, but it’s interesting.

The remedy is in an entry for the herb ashthroat, which may be the herb now called verbena or vervain. It is first prescribed for hardening of the arteries, stones in the bladder, liver disease, and wound care. Its use in snake-bite and spider-bite is unremarkable, following the generic pattern of boiling pounded twigs and leaves in wine, and applying it to the wound.

For the bite of a mad dog, the verbena (probably crushed) is mixed with an equal amount of wheat seeds. This mixture is laid into the open wound. The wheat is there to absorb moisture, probably to draw out the venom. When it appears to be swelled up with moisture, it is removed from the wound and tossed to the chickens. This is a test: will the chickens eat it? If the chickens refuse to touch it, the procedure must be repeated with fresh verbena and wheat until all toxicity is gone.

I don’t know what to make of this test. They seem to assume that chickens can sense the infection in the grain. Or is this just a test of how successfully the wound is being drained at all? Will chickens avoid grain that has gotten blood on it? This seems unlikely to me; the chickens I’ve known don’t mind picking each other bloody. Has anyone in the last 1000 years tried it, or has this chicken lore died out? My father, an amateur chicken farmer, didn’t know either. The internet is only interested in whether chickens can get rabies (answer: no, but isolated cases happen).

Other Herbarium entries recommended for the bite of a mad dog are used in conventional ways, just laid into the wound plain or infused in wine. Only this one treatment has the chicken test.

Bald’s Leechbook suggests using houndstooth, or houndstongue, to treat dog bite. This plant is toxic to cattle because its natural insecticides are so powerful. It has a long history in herb lore; it was regularly used in medicine into the modern age, decocted into various brews and teas. But it’s likely that its use for dog-bite is mostly due to its leaves being shaped like a dog’s tongue. Natural magic’s first principle was that anything shaped like the body part or attacker could help with the ailment.

 

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Henbane and Horehound

Toothache must have been a frequent problem in medieval times. With our standard of dental care, we lose awareness of just how chronic and potentially dangerous tooth problems can be. From chronic minor tooth pain (the sort that gets “referred” to other teeth so you don’t know where it’s coming from) to lethal infections, teeth were a never-ending problem.

Bald’s Leechbook suggests chewing pepper for toothache. When Bald’s book was compiled in the 11th century, this traded spice from southern India must have been restricted to castle cooking and medicinal use. Would pepper help with teeth? It might; it has antibiotic properties.

When pepper was not available, doctors turned to a very dangerous European plant: henbane, which is also called Stinking Nightshade. Henbane is very poisonous, but used with care, it is a narcotic and can induce hallucinations. Bald’s recipe calls for its root to be boiled in vinegar or wine, as a liquid to soak the tooth in. However, Steve Pollington in Leechcraft suggests that the primary reason that they turned to henbane was not that it was an effective narcotic, but rather because its fruit is shaped like a tooth. It’s possible!

Sore throat and lung ailments both enter the leechbooks as coughing. “Against coughing” there are many remedies, but in first place comes horehound. We know this as an old-fashioned candy flavor, but it actually refers to two different plants, the black and the white horehound.

White horehound is a kind of mint, and it is still used to make throat lozenges. However, when it’s boiled, it becomes bitter and nauseating, and works as a purgative. Black horehound is a completely different plant, Ballota nigra. It was known to farmers as the plant that cattle refused to eat because it had such an unpleasant smell. When boiled, however, it may be less volatile. Both are good for lung ailments; a modern herbal reference suggests that black horehound is the more effective medicine, acting directly on mucous membranes.

But Bald’s recipes call for “marrubium,” the Latin name for white horehound. He calls for it to be boiled with honey in some cases, or boiled in combination with many other herbs (betony, agrimony, wormwood, lupin, radish…it’s a long list). When boiled with these other herbs, it can be used to make a barley porridge. Bald suggests treating a man with serious lung disease by giving him warm herbal drinks first thing in the morning, alternatively at times feeding him the medicated barley porridge.

In one suggestion, the patient fasts overnight, takes the herbal brew on an empty stomach and immediately lies down on his right side, with his arm stretched above his head. I don’t know what the effect would be. Any guesses?

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Breast milk and virgins

Medieval herbal and traditional remedies come mainly from native Celtic or Germanic roots, not from the Greco-Roman tradition that they considered more scientific. And although only a few of the remedies include women in the actual recipe, they tell us something about traditional Europe’s attitude toward women. In a nutshell, women are good. They can mediate healing in ways that men can’t.

First, they produce milk. Breast milk turns up in five remedies, leaving it very unclear whether its use was “medical” in our sense, or magical. Other kinds of milk can be used in simple ways, as the base for active ingredients; “woman’s milk” is clearly a special ingredient, not just a base.

Bald’s book suggests using it as an eye drop or wash for growths on the eye, particularly the emergence of a “red sponge.” They’re almost certainly referring to a condition known as “Surfer’s Eye.” Every medieval fisherman can be considered a surfer, for these purposes. Being outdoors in the salt spray, with strong wind and bright sun, was very stressful for their eyes. Pterygium is a reddish or yellow growth that begins to cover the eye. It’s considered benign, but it can grow out over the cornea. It seems likely that many old fishermen, having survived storms and accidents, would be blind, and often from double-eye pterygium.

Pterygium in our time is treated with lubricating drops until it becomes urgent enough for surgery. Breast milk has some outstanding qualities, being sterile and filled with fat molecules. However, you’d think sheep’s milk (their most common dairy) would have the same qualities, and no other milk is recommended as an eye drop.

For “spots” on the eye, breast milk was used as a clean-up fluid after some rather nasty things were dropped into the eye. One of the ingredients has an uncertain translation; it could be sulfur. The other ingredients are burnt salt, and ink. They’re pulverized with a mortar and pestle and sprinkled into the eye, which is then washed up with a bit of wool dipped in water. Breast milk as eye drops come last, as a soothing wash.

Could breast milk have brought needed antibodies, as well as sterile water and fats? It’s possible, but it seems like giving them scientific credit in this case is too big a stretch. Breast milk probably is a good eye-drop at need. But after burnt salt and ink? Worse, there are two alternative eye drops suggested for the pterygium growth: hot pigeon’s or swallow’s blood. Again, it’s quite possible that blood would make a decent eye lubricant and perhaps help with disinfecting. When we see the requirement for pigeons and swallows, though, it sounds like magical thinking. “Birds have sharp eyes, so of course their blood is good for eyes.” The logic may have run a little bit differently, but not much. One of the basic principles of natural magic is that like treats like.

Breast milk also works as an ear-drop mixed with cilantro (coriander) juice. Like other ear-drops, it is first warmed in an oyster shell, which works as a tiny pitcher. Here again, we are left to wonder if its antibodies and white blood cells worked directly against infection.

As a fourth human-dairy product, the Lacnunga book has a very weird fever remedy: “take a snail, and cleanse it, and take the clean lather and mix it with a woman’s milk; give it to him to drink.” Just when we get to the remedy that suggests drinking the stuff, they include a snail.

Fifth and last, breast milk was a component of treating palsy of the face, perhaps what we’d call Bell’s Palsy. One way to treat the palsy was to source the problems to the ear; the mixture of cilantro/coriander and breast milk was again recommended. But for more extreme cases, the woman had to be nursing a baby boy, the leaves had to be dried before use, and the resulting mixture had to be applied to the paralyzed cheek with a blue cloth (and then dripped into the ear). There’s no other example of this “baby boy” reasoning, so we can only guess. Things seemed more magical if they crossed boundaries, so perhaps a woman’s milk being fed to a baby male seemed to combine something of both sexes.

Second, women can exert a powerful influence over nature by being virgins. Here, the “science or magic?” question is unnecessary. Let’s look at the prescription-virgin treatment for a cyst or swelling on the heart (and no, I don’t know how this would have been diagnosed without surgery). A cyst or swelling of some kind was called, in Anglo-Saxon, a wen.

“If wens ail a man at the heart: have a virgin go to a spring which runs straight eastwards and scoop one cup full out against the stream, and sing on it the Credo and Pater Noster and pour it then into another container; and….do likewise until you have three; do likewise for nine days; better will soon come to him.”

I think we can say with confidence that when this remedy was first used, Christian creeds and prayers were not the charms recited. Nine is not a significant number in Judeo-Christian tradition, but it is very significant in the Norse one. Odin hung on the world-tree, gaining secret runic knowledge, for nine days.  Many charms associated with Odin’s secret lore bring in 9’s. We’ll talk more about charms and runes in later entries.

What can we make of these remedies? If nothing else, it’s clear that women were considered a good influence on nature.

Source: Pollington, Leechcraft.

 

 

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Animals in medieval medicine

In the entries for eye salves, we first start to see an odd trend in these traditional remedies. While most of them use herbs, a few use fat or gall from animals. Is this medicine or magic?

Both of the leechbooks (lists of remedies in Anglo-Saxons) provide eye salves made from animals, and they are similar but not identical. Bald’s book has a very simple one: put fox’s fat into your eyes. In fact, do it every night for 30 nights as a general cure-all.

Bald’s book suggests another eye salve that sounds more difficult in every way. It starts with oil and a bumble-bee’s honey. Honey was often used to make medicines taste better or as a salve base, but this one specifies a wild bee whose honey is probably difficult to obtain. Into this base, add gall from a raven and a salmon.

Lacnunga has two similar salves. In one, the gall from a raven and a salmon are added to some herbs. A little “sharp juice” makes it a bit wetter, and it’s dropped into the eye through the medium of a piece of linen. In the other salve, bumble-bee’s honey forms the base, with fox fat and bone marrow from a roe deer.

It’s hard to know what to make of these directions from a modern view. It’s impossible to exclude an element of magic, since the bird must be a raven, not just any bird. Is the gallbladder of a raven distinct from others? It’s plausible that bile produced by seed-eating or worm-eating or scavenging birds is different, since they are digesting different things. What about bile from a salmon? I just don’t know.

It’s possible that there’s a unique chemical signature to the honey of the wild bumble-bee, as opposed to all of the wild or domesticated honey bees. Is it likely that this chemical is a break-through substance for treating eyes? It doesn’t seem likely.

It seems likeliest that the efficacy of the salves depended most on the ingredients being hard to obtain. It wasn’t hard to find bile from common farm animals, and pigs are known for production of fat, even in medieval times when pigs foraged for their own food. Foxes are lean creatures; even if you caught a fox and butchered it mainly for its fat, you’d have a small quantity. Same with salmon’s and ravens’ gallbladders or stomachs: small quantities, hard to obtain.

Bumble-bees do make honey, but there’s a reason they aren’t called honey bees. Honey bees stockpile honey for wintering over, but bumble-bees store only a few days’ worth of honey. It would take skill and patience even to find where it was stored, let alone bring it back.

In general, honey has some antibiotic properties, and bile is a mix of powerful chemicals. Ox gall, Wikipedia tells us, has cholesterol, lecithin, taurocholic acid, and glycocholic acid. The other kinds of bile might have any of six acids, which occur in the form of salts. Mixed into water, the salts break down into amino acids like taurine and cysteine.  Taurine crosses the blood-brain barrier and acts as an anti-oxidant; it is a component in today’s energy drinks.

So what happens when you take a bile from specific fish and birds, mix it with hard-to-obtain wild honey, and add fox fat? Really, anything could happen. it’s possible that some chemicals form powerful antibiotics. It’s also possible that representatives of air, land and water unite their magical powers to overwhelm flying venom. Until someone tests these substances, we won’t know.

As before, much thanks to Steve Pollington’s Leechcraft for these medicinal recipes.

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Worms in the eye

In traditional pre-Christian European ideas, outside attacks caused many illnesses. This idea was probably considered primitive by Roman-trained doctors, who had a more scientific system based on imbalance of the body’s humors. In our time, we can see merit in both ideas.

One of the major sources of attack was the worm, or in Anglo-Saxon, “wyrm.” Again, I am leaning on Stephen Pollington’s Leechcraft to describe wyrm attacks. Pollington points out that wyrms could be snakes, dragons, parasitic worms, or some other invisible kind. (Earthworms had their own designation, renwyrm, and were not considered harmful. In fact, applying a crushed earthworm to some injuries was healing.) I’ll continue to use “wyrm,” their spelling, when it has this wider meaning than our “worm.”

The snake is one of the oldest mythological enemies of mankind. In addition to the Bible’s most ancient story of a serpent harming the first humans, the Indic and Hittite writings tell of first humans and heroes having to do battle against serpents. In contrast to the Bible’s story, in which the serpent wins the round and is rebuked directly only by God, the Indo-European myths portrayed the hero as the winner. The struggle might be to the death, as it is in Beowulf, but the hero slays the serpent.

The Anglo-Saxon medical directions and charms don’t distinguish what sort of wyrm might be attacking a patient. Some of the directions just mention wyrm attacks. Others specify that the wyrms are inside an organ, attacking it, which could mean parasitic worms. Of course, people in the past had ample evidence that worms really did attack humans. From tapeworms to ringworms to maggots, it was just fact.

One of the eye remedies in Bald’s collection is for wyrms in the eyes. We don’t know if they were visible worms, like maggots, or something invisible and presumed to be there.

The remedy for wyrms in the eye entails minor surgery. The doctor was to flip the eyelids up and lightly score them with his knife. Then he was to squeeze the juice of the plant celandine into the cuts. This, said the directions, would heal the whole problem. The wyrms would die, and the eye would heal.

Celandine is of the poppy family, and when its stem is cut, a yellow-orange latex oozes out. This juice has antibiotic and analgesic properties, but apparently if it’s put into a wound in this pure, strongest form, it’s highly irritating. In effect, it cauterizes the wound without any literal burning agent like a hot needle or knife.

Celandine has high amounts of an alkaloid called coptisine. The alkaloid is bitter and can be toxic to some kinds of cells. Coptisine used in Chinese medicine, though obtained from a different plant. While opium, also in the poppy family, has some coptisine, celandine apparently has much higher levels. Celandine has a number of other alkaloids, and in different strengths, it can be an analgesic. It may have anti-cancer effects as well.

Putting celandine in its strongest form into an eye that has already been scored with light cuts seems like a pretty radical and extremely painful treatment. Considering it in this light, it may have been used only when there was direct evidence that not only wyrms, but actually worms — maggots or some parasite — were present.

The Herbarium, a third manuscript with much Latin influence, suggests toning down the celandine’s effect by pounding its root with wine, and adding honey…and pepper. I can’t help thinking this one hurt pretty badly too. But if these remedies worked at all, which they probably did, any pain was better than going blind in a survival society. There was no room for error in that world; if any member of a family went blind, it might bring them all down. Next, I’ll look at eye salves that included some even more unusual ingredients.

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The raven’s eyes

Until more researchers at places like Nottingham University recreate Anglo-Saxon medicinal recipes, we won’t know if there are hidden secrets like the surprisingly effective antibiotic made from leeks and garlic. Some of the others sound possibly effective, now that we know one was. And some are just plainly no good, from our perspective.

The most outstanding no-good remedy involving a live bird tells us more about magical thinking than about medicine. How does the world work? What is permissible to do, in a quest for health? Does it matter if you know why it works?

The raven has special status in nearly all polytheistic/nature religions. In Norse religion, the raven was Odin’s special bird. Odin’s two ravens were named Thought and Memory. They flew through the world, bringing him back news. The Celts — Gauls, Britons and Welsh — who preceded the Germans in Europe also revered the raven. Ravens acted as messengers for their gods, too. According to Celtic legend, the Tower of London must be guarded by ravens. The raven’s special status must have been cemented by the Roman legions who occupied Celtic Europe. The cult of Mithras was the most popular religion at the time, and the raven represented a messenger god — and was one rank in initiation — here, too.

If the raven is a divine messenger, then its eyes matter a lot. It has to see what’s happening, right? I hope you can see where this is heading…or maybe I hope you can’t.

Eye infections often led to blindness, and blindness was a terrible disability in the Middle Ages. It was worth doing just about anything to avoid becoming blind. We feel that laboratory testing on animals is a legitimate act (most of us do anyway), and they felt that mutilating a raven was also just fine.

“Take a living raven, take the eyes out of it and, still living, bring it into water. Put the eyes on the neck of the man who needs them, and he will soon be well.” (Pollington, Leechcraft)

There’s no further explanation in Bald’s Leechbook. Immediately after this statement, the list turns to ten more remedies that don’t involve a mutilated living bird. As is generally true, the doctor’s training will help him know when to choose which remedies, so apart from the eyes being swollen, there is no guidance about which cases require a raven.

It’s likely that by Christian times, the raven’s eye remedy was rarely used, and it was only included for completeness. But we don’t know. It may have been viewed as the really effective (but rather extreme) remedy to be tried last when the herbs failed. It’s the only remedy of this type that I could find in the two texts. It’s very clearly magic, not medicine.

I don’t know any explanation for why the raven had to be put into water while its eyes were put onto the patient’s neck. Probably the bird had to be quickly drowned so that it could not take its eyes back, while the eyes were still living. Then the power was transferred to the human, as the bird died. It’s also possible that they had a whole program for teaching ravens to fly under water. If so, that experiment has been recreated in modern times, though it failed.

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Bald’s eye salve: a modern story

After remedies for head pain, the medical books turn to eye problems. It’s very clear that swollen and infected eyes were a serious issue in that time, because both books have a number of remedies. And here, we find a striking story from 2015: one of the remedies actually works, and works well.

The remedies have different preparation methods, and while most of them required only direct mixing or at most boiling the ingredients together, some of them demanded a period of time for the ingredients to sit. It might be three days, or seven, or at most, nine. Nine was a special number in the old religion.

The remedy that the University of Nottingham chose to test had a time requirement; it also required a particular type of vessel: bronze. Its ingredients list was simple compared to others, otherwise: Leeks and garlic, with ox’s gall (stomach bile), steeped in wine for nine days in a bronze dish. At the end of this period, it was to be strained with a cloth, which was probably linen. The resulting liquid was the medicine for a swollen eye.

Nottingham used glass lab equipment, but they included a brass plate so that chemicals could react with it. They chose a heritage local wine; in the Medieval Warm Period, it was easier to grow grapes in England than it has been since, so it seemed certain that anyone using this remedy in the past would be using local vintage.

To test the efficacy of the resulting liquid, the lab prepared some petri-dish cultures of collagen and staphylococcus bacteria. Some culture dishes were also treated with the separate ingredients; garlic and wine, in particular, both have antibiotic properties. But a staph infection is hard to kill, so not much was expected, neither did it happen. None of the separate ingredients had a measurable effect.

However, after nine days, the combination liquid was filtered (I’m not sure if they used linen but I hope so). This liquid was applied to one of the staph cultures. After 24 hours, it was examined under a microscope. All of the lab personnel were astonished to find that most of the staphylococcus bacteria were dead. “About 1 in a 1000 survived,” they report.

2 + 2 = 5! The ingredients in combination had a power that none of them had together.

The test was repeated four times. Each time, the test replicated the initial results. Then something even more surprising came out. They diluted the liquid:

The team then went on to see what happened if they diluted the eye salve – as it is hard to know just how much of the medicine bacteria would be exposed to when applied to a real infection.  They found that when the medicine is too dilute to kill Staphylococcus aureus, it interfered with bacterial cell-cell communication (quorum sensing).  This is a key finding, because bacteria have to talk to each other to switch on the genes that allow them to damage infected tissues.  Many microbiologists think that blocking this behaviour could be an alternative way of treating infection.

Clearly, in a time before any chemistry was understood, someone had learned through trial and error that this combination of materials created a chemical reaction that resulted in a new compound. I wonder if Nottingham has continued to experiment with the variables, for example taking a sample from the mixture each of the nine days, and finding out at what point its starts to change.

Here is the University of Nottingham press release, with a video in which the key participants discuss the experiment.

 

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